The Lysis of Cholera and El Tor Vibrios

Isolation of Hemagglutinative Non-el Tor Cholera Vibrios.

During 1963, El Tor cholera spread through Thailand and Burma, and finally appeared in the Chittagong area of East Pakistan in November (Yen et al., East Pakistan MIed. J. 8:22, 1964). With disease caused by the El Tor vibrio within 80 km of areas under study by this laboratory, all vibrio isolates which agglutinated in cholera antisera were screened by the chicken erythrocyte agglutination tes...

Technical considerations of cholera vaccines and some results of cholera - El-Tor mass immunization

Preselection of hemolytic variants of el tor vibrios.

Historically, hemolytic activity in tube tests was regarded as the sine qua non in the differentiation of El Tor from classical cholera vibrios. However, in the recent outbreaks of cholera in Southeast Asia, many strains of agglutinable vibrios have been isolated which share a large number of properties ascribed to El Tor vibrios (and not the classical variety), but which lack hemolytic activit...

technical considerations of cholera vaccines and some results of cholera - el-tor mass immunization

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Purification and characterization of a hemolysin produced by Vibrio cholerae biotype El Tor: another toxic substance produced by cholera vibrios.

A thermolabile direct hemolysin from an El Tor cholera vibrio strain has been isolated and partially characterized as a simple protein of ca. 20,000 molecular weight. In addition to its hemolytic activity, the hemolysin is cytotoxic, cardiotoxic, and rapidly lethal. In these respects it resembles the thermostable direct hemolysin/cytotoxin/cardiotoxin/lethal toxin of Vibrio parahaemolyticus and...